IV NAD in Edmonton
We offer Edmonton NAD+ IV for Energy, Longevity & More
“NAD” refers to the chemical backbone irrespective of charge.
“NAD+” and “NADH” refer to the oxidized and reduced forms respectively.
Much of the renewed interest in NAD can be attributed to the sirtuins, a family of NAD+-dependent enzymes (protein deacylases) - SIRT1-7.
Sirtuins, regulate a wide variety of proteins involved in processes that include mitochondrial metabolism, inflammation, autophagy, circadian rhythms, and apoptosis.
NAD+ is required for approximately 500 different enzymatic reactions and present at about three grams in the average person.
Only neurons can import NAD+, other cells must synthesize it either from tryptophan or forms of vitamin-B3 such as nicotinamide (NAM) or nicotinic acid (NA)
To maintain NAD+ levels, most NAD+ is recycled (via salvage pathways)
The majority of NAD+ is salvaged from NAM, or from the various forms of niacin (Vitamin B3) taken up in the diet including NAM, NA, NR and NMN.
The well known precursor NR is converted to NMN
Increases in NAD+ promote cognitive and sensory function.
Liver - NAD+ signaling pathways are known to protect the liver from fat accumulation, fibrosis and insulin resistance. NAD boosting appears to not only improve the health of the liver, but also increase its capacity for regeneration and protect it against hepatotoxicity.
Kidneys - Reduced levels of NAD+ in aged kidneys (with a corresponding decrease in sirtuin activity) seem to be responsible for reduced kidney function and resilience with age.
Muscle - Treatment of old mice with NAD+ precursors, such as NR and NMN, dramatically improves muscle function. NR increases the number of muscle stem cells and enhances muscle regeneration in old mice.
Heart - NAD+ levels are critical for normal heart function and recovery from injury as treatment with NAD+ precursors also improves heart function.
Cancer - In cancer, the role of NAD+ is less clear: One one hand, NAD+ will boost mitochondrial respiration and downregulate glycolysis, counteracting Warburg metabolism that cancer cells prefer whereas on the other hand, raising NAD+ may promote DNA repair helping cancer cells thrive.
Neurons - NAD+ levels are key to neuronal function and survival. NAD+ precursors have shown promise in delaying the effects of several neurodegenerative diseases including MS (Sirt1!).
Longevity - steady decline in total NAD+ levels over time is a natural occurence for all life. This decline, along with the decreased activity of NAD+ signaling proteins, is believed to be one of the major reasons organisms, including humans, age.
Physiological levels of NAD+ can be achieved by ingesting 15 mg of niacin daily.
It is well known that NAD+ levels decline with age and increasing NAD+ has been shown experiementally to extend lifespan.
NR and NMN are orally bioavailable endogenous molecules, making them the molecules of choice for animal experiments and human clinical trials whereas Niacin (NA or Nicotinic Acid) is often limited by unpleasant side effects that include flushing and itching.
Neurons can directly uptake NAD+. Whereas with other cells, NAD+ and NMN undergo extracellular degradation to generate permeable precursors that can be taken up by cells. NAD+ is cleaved to NMN and AMP.
Human NAD Data
A randomized study in 12 human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg.
A clinical trial with 140 participants showing that orally administered NR gives a dose dependent increase in NAD+ from 250–1000 mg/d plateauing at a 2-fold increase in NAD+.
A 2019 study from Grant demonstrated distribution of 750mg of IV NAD over a 6 hour period. The results implied that initially there is rapid uptake of NAD+ when given intravenously.
Hyperbaric Oxygen and NAD+
The neuroprotective effect of Hyperbaric Oxygen is thought to be, in part, through upregulating Sirt1 which is of course NAD+ dependant (NAD+ positively regulates the activity of Sirt1). HBO increases the expression of Sirt (See Hu 2017).
Theoretical synergy exists between NAD and Hyperbaric treatment as both are drivers of Oxidative Phosphorylation and the effects are thought to be additive in terms of cellular metabolism.
Hyperbaric treatment is thought to increase ATP and therefore the activity of NAMPT (enzyme that creates NAD+) thereby promoting the production of NAD+
Our Naturopathic Doctors give both low dose and high dose NAD+ IV Treatments
NAD+ is often administered in doses ranging from 250mg-2000mg. However, most commonly
Our Naturopathic Doctors have seen awesome results for fatigue in our Edmonton patients. We also consider NAD IV with fibromyalgia, subtance abuse withdrawal, and promoting longevity. For fatigue we usually administer NAD+ over about an hour in doses of 250mg to 500mg.
As mentioned above, as a patient ages, NAD+ levels decline therefore the older a patient is, the more likely they are to experience benefits from IV NAD.
Why give NAD Intravenously?? When NAD is given orally, it has poor oral, and is broken down into nicotinamide primarily, NR and NMN.
Although we can try to prolong the effects of IV NAD with oral NAD+ precursors, we find the most clinically effective strategy is regular IV treatment. Oral treatment with precursors just does not have the same spark that IV NAD+ seems to have.
IV NAD in Edmonton
NAD+ side effects
Rapid infusions of NAD+ causes profound nausea, headaches, chest pressure, and rarely diarrhea.
Our Naturopaths try and run NAD less than 4mg minute.
NAD+ and Withdrawal
For withdrawal from various substances, NAD doses usually given between 1500-2000mg on their first day with descending doses on subsequent days for a total of 3-5 days however up to 10 days has been reported.
NAD+ is usually given for alcohol or opioid withdrawal.
Resources: David Sinclair