IV NAD in Edmonton
Energy, Longevity & More
“NAD+” and “NADH” refer to the oxidized and reduced forms respectively.
Much of the renewed interest in NAD can be attributed to the Sirtuins
Sirtuins, regulate a wide variety of proteins involved in inflammation & autophagy.
NAD+ is required for approximately 500 different enzymatic reactions
It's present at about three grams in the average person.
Only neurons can import NAD+, other cells must synthesize it.
It's made from tryptophan or forms of B3 such as nicotinamide (NAM) or nicotinic acid.
To maintain NAD+ levels, most NAD+ is recycled (via salvage pathways) from NAM.
The well known precursor NR is converted to NMN
Liver - NAD+ pathways are known to protect the liver from fat accumulation.
NAD+ boosting increases its capacity for regeneration.
Kidneys - Reduced levels of NAD+ are related to reduced kidney function with age.
This is with a corresponding decrease in Sirtuin activity.
Muscle - Treatment of old mice with NAD+ precursors improves muscle function.
NR increases the number of muscle stem cells and muscle regeneration in old mice.
Heart - NAD+ levels are critical for normal heart function.
Recovery from injury as treatment with NAD+ precursors improves heart function.
Cancer - In cancer - on one hand, NAD+ will downregulate glycolysis.
However, raising NAD+ may promote DNA repair helping cancer cells thrive.
Neurons - NAD+ levels are key to neuronal function and survival.
NAD+ precursors have delaying the effects in several neurodegenerative diseases.
Longevity - Steady decline in NAD+ levels over time is a natural occurrence for all life.
This decline is believed to be one of the major reasons organisms age.
Physiological levels of NAD+ can be achieved by ingesting 15 mg of niacin daily.
Increasing NAD+ has been shown experimentally to extend lifespan.
NR and NMN are orally bioavailable endogenous molecules.
Niacin (NA or Nicotinic Acid) is limited by unpleasant side effects like flushing.
Neurons can directly uptake NAD+.
Whereas with other cells, NAD+ undergoes degradation to generate precursors that can be taken up.
Human NAD Data
A randomized study in 12 human subjects showed that NR raises NAD+ by as much as 2.7-fold in human blood with a single oral dose of 1000 mg.
A clinical trial with 140 participants showing that orally administered NR gives a dose dependent increase in NAD+ from 250–1000 mg/d plateauing at a 2-fold increase in NAD+.
A 2019 study from Grant demonstrated distribution of 750mg of IV NAD+ over a 6 hour period. The results implied that initially there is rapid uptake of NAD+ when given intravenously.
Hyperbaric Oxygen and NAD+
The neuroprotective effect of HBO is thought to be, in part, through upregulating Sirt1.
This is of course NAD+ dependent (NAD+ positively regulates the activity of Sirt1).
Theoretical synergy exists between NAD and Hyperbaric treatment.
Both are drivers of Oxidative Phosphorylation and the effects are thought to be additive.
Hyperbaric treatment is thought to increase NAMPT (enzyme that creates NAD+).
Our Naturopathic Doctors give both low dose and high dose NAD+ IV Treatments
NAD+ is often administered in doses ranging from 250mg-2000mg.
We have seen awesome results for fatigue in our Edmonton patients.
We consider NAD+ with fibromyalgia, withdrawal, and promoting longevity.
When given orally, it's broken down into nicotinamide primarily and NR and NMN.
Resources: David Sinclair